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1. Prescription Drug Costs
2. Prescription Drugs That Cause Kidney Stones
3. Prescription Drugs That Cause Dry Mouth

• Several medications have been studied as treatments for pathological gambling, and the range of medication classes—opioid antagonists, serotonin reuptake inhibitors (SRIs), mood stabilizers—that have been tested reflects the different ways pathological gambling is categorized (Table 1). Because no medication currently is approved by the Food and Drug Administration for treating pathological gambling, patients should be informed of off-label use of medications for pathological gambling.
• Opioid Antagonists. Pathological gambling and substance abuse have the following characteristics in common: 1) repetitive or compulsive engagement in a behavior despite adverse consequences, 2) diminished control over the problematic behavior, 3) an urge or craving prior to engagement in the behavior, and 4) a hedonic thrill when taking part in the behavior.
• Feb 16, 2017  Imagine a prescription drug that makes you gamble, have sex, overeat or go binge shopping. Antipsychotic drug linked to compulsive gambling.
• Parkinson's disease meds increase risk of compulsive gambling, shopping, binge eating. The primary risk factor for ICDs is the use of a class of Parkinson's disease medications called dopamine agonists, which help control tremors and other Parkinson's symptoms. These drugs include pramipexole (Mirapex®) and ropinirole (Requip®).
• While the most common Abilify side effects are minor, serious side effects have been reported. Some side effects, such as tardive dyskinesia, can cause permanent injury even after a person stops taking the drug. And some conditions may even become worse after stopping aripiprazole.

To the Editor: We are intrigued by the recent article by Bostwick et al on the emergence of impulse control behaviors after treatment with dopamine agonists. It is amazing how these gambling and hypersexuality adverse effects occur and then seem to immediately abate simply by discontinuing the Parkinson disease medication without need for any additional addiction-related treatment. Ropinirole was recently investigated in a phase 4 clinical trial as a treatment for sexual dysfunction secondary to antidepressant pharmacotherapy,² which speaks to its possible effects on sexual behavior. Dopamine agonists may affect the mesolimbic pathway, as do drugs like cocaine and methamphetamine, whose behavioral properties are attributed to this dopaminergic activity; sexual compulsivity is a well-established adverse effect of these medications. Furthermore, dopamine dysregulation syndrome, an addictive use pattern of dopamine agonists, causes the same behaviors observed in cocaine-dependent patients, such as punding, a stereotypical motor behavior characterized by an intense fascination with the repetitive handling and examination of objects, particularly mechanical ones. Examples of punding include picking at oneself, taking apart watches and radios, or sorting and arranging common objects (eg, lining up pebbles, rocks, or other small objects). People engaging in punding find immersion in such activities comforting, even when they serve no purpose, and generally feel frustrated when diverted from them. Punding is thought to be related to dopamine use and has been observed in (meth)amphetamine and cocaine users, as well as in some patients with Parkinson disease, gambling addictions, and hypersexuality.

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Prescription Drug Costs

Prescription Drugs That Cause Kidney Stones

This drug appears to lead to compulsive behaviors in some people. This may include hyper-sexuality, binge eating, shopping addiction, and compulsive gambling. In addition to Abilify, other drugs in this class include Abilify Maintena, Aristada, and any other brand of medication containing aripiprazole. Drugs don’t cause gambling problems just like Jack Daniels causes a drunk to be a drunk. It’s weakness that causes these problems. Gambling addiction and drinking excessively was around long before these drugs was even thought of.

We have questioned whether drugs like cocaine precipitate these psychiatric issues or whether they preexist the drug use. Robinson and Berridge suggest that prior use of certain drugs sensitizes the mesolimbic reward pathways, producing neuroplastic effects on the brain and increasing the likelihood of future abuse/dependence. Because impulse control disorders such as pathologic gambling and sexual compulsivity are associated with dysfunction in the same neural circuitry, we propose that use of these substances may directly activate these pathways (precipitating acute symptoms of compulsive gambling and/or hypersexuality) and over time may produce neuroplastic changes in these pathways (leading to chronic impulse control behaviors). With cocaine and other dopaminergic-stimulating medications, there may be a temporal use interval necessary to produce adaptive synaptic changes in the mesolimbic system of patients using these substances, and future studies should focus on the timeline of drug use.

In addition, we have treated hundreds of cocaine abusers with comorbid gambling addiction and/or hypersexuality for whom behavioral remission was not automatic once they stopped using cocaine. In fact, most of our patients need long-term treatment in addition to discontinuation of the substance. It would be useful to study the differences in cocaine-induced gambling and/or hypersexuality and dopamine agonist-induced behaviors. A long-term follow-up of the patients in the study by Bostwick et al would also be useful to determine whether true behavioral remission was achieved.

References

Prescription Drugs That Cause Dry Mouth

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